If you are going to fly into Tampa and stay over at least one night before driving into the Orlando area, that is doable. It's a heavy, heavy trafficked area, and the drive out of Tampa is not a good one (during regular business hours). If there is an accident on I4 you are stuck until it clears. (Accidents during the week are frequent).
So, all that to say Tampa is possible, or feasible but you'll want to have some plan in place first. A nice drive over is on SR 50 (north of Tampa). It's longer in some ways, but Old Florida and a very nice drive.