I'm pretty organized so we make the bed every morning and keep our toiletries all together. I unpack when we arrive and put the luggage in the closet so there isn't stuff laying around. I bring a bag for dirty laundry and keep that in the closet as well.
Basically, mousekeeping comes in every fourth day and leaves clean towels and takes the trash. On the eighth day, you would get a complete cleaning.
We're in the room so little that it never gets very messy.